- Oral presentation
- Open Access
Not all LGE is the same. Scar contrast volume of distribution is lower in HCM than in infarction
© Treibel et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Acute Myocardial Infarction
- Late Gadolinium Enhancement
- Inversion Recovery
- Biological Interest
- Contrast Volume
Focal fibrosis is visible as late gadolinium enhancement when using inversion recovery (IR) imaging late after a contrast bolus and carries major clinical import. The IR technique results in high sensitivity to regional T1 variation but sacrifices absolute quantification meaning that differing degrees of focal interstitial expansion will look the same (bright).
We hypothesized that LGE in different disease processes would have different degrees of interstitial expansion. We used equilibrium contrast CMR (EQ-CMR)1, to measure the degree of interstitial expansion by measuring the volume of distribution of contrast, Vd(m).
HCM LGE had a lower Vd(m) than infarct LGE (0.43 vs 0.56; p=0.013). There was no difference between remote myocardial Vd(m) between the diseases (0.30 vs 0.33; p=0.35).
LGE in HCM has less interstitial expansion than LGE in infarction. EQ-CMR allows differentiation of LGE in degrees of interstitial expansion and, by inference, degrees of myocyte loss. The presence of residual myocytes within HCM LGE may be of biological interest, potentially representing, for example, an arrhythmic substrate.
British Heart Foundation; National Institute for Health Research.
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