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Association between aortic stiffness, carotid vessel wall thickness and stenosis severity in peripheral arterial occlusive disease: a comprehensive MRI study
© van den Bosch et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Pulse Wave Velocity
- Stenosis Severity
- Peripheral Arterial Occlusive Disease
- Aortic Pulse Wave Velocity
- Vessel Wall Thickness
Aortic pulse wave velocity sampled in the descending aorta is associated with maximal stenosis severity, visually scored on CE-MRA in patients with PAOD whereas stenosis severity is correlated to a lesser extent with carotid vessel wall.
In atherosclerosis, arterial wall thickening and stiffening precede luminal narrowing. MRI is well-validated for imaging vessel wall thickness (VWT) and stiffness expressed in pulse wave velocity (PWV, defined as the propagation speed of the pressure or flow wave through the aorta). Contrast-enhanced MR angiography (CE-MRA) has evolved into a reliable tool for stenosis detection in peripheral arterial occlusive disease (PAOD). The purpose of this study was to use a comprehensive 3T MRI-approach for comparing stenosis severity on CE-MRA with VWT, sampled in the common carotid artery, and PWV, sampled in the descending aorta.
Four transverse images of the common carotid artery were obtained by multi-slice 2D dual inversion recovery black-blood (DIR) fast gradient-echo (Figure 1B) with spectral selective fat suppression. A flexible 2-element surface coil was used and positioned on the neck. Inner and outer lumen contours were manually determined (Figure 1C), defining measurement of mean vessel wall area (VWA) per slice.
PWV was assessed for the descending aorta by applying two one-directional through-plane velocity-encoded MRI acquisitions, planned perpendicular to the aorta and transecting the proximal and abdominal descending aorta, respectively (Figure 1D). PWV was obtained from systolic wave propagation analysis based on the transit-time method (Figure 1E).
PWV was compared with carotid VWA indexed for body surface area and maximal stenosis severity class detected with CE-MRA.
PWV in the descending aorta is associated with maximal stenosis severity, visually scored on CE-MRA in patients with PAOD whereas stenosis severity is correlated to a lesser extent with carotid vessel wall.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.