- Poster presentation
- Open Access
CMR derived MAPSE and TAPSE Measurements in hypertrophic cardiomyopathy: comparison to healthy volunteers
© Abdel-Aty et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Hypertrophic Cardiomyopathy
- Gender Related Difference
- Short Axis Slice
- Tricuspid Annular Plane Systolic Excursion
- Mitral Leaflet
Mitral and tricuspid annular plane systolic excursion (MAPSE and TAPSE respectively) measurements are rapid, sensitive and reproducible means to assess left and right ventricular (LV, RV) function providing relevant prognostic information. Currently, only scarce data exists regarding the prognostic value of M/TAPSE in hypertrophic cardiomyopathy (HCM).
We hypothesized that M/TAPSE is reduced in HCM patients due to dysfunctional longitudinal contraction patterns and compared myocardial longitudinal function in HCM to a large cohort of healthy volunteers.
Both M/TAPSE were significantly higher in volunteers compared to HCM patients (MAPSE: 14±4 mm vs. 9±5 mm; p<0.0001 and TAPSE: 20±5 mm vs. 18±8 mm; p=0.002). Left ventricular EF was significantly higher in volunteers compared to HCM patients (65±9%; vs. 62±10% p=0.0003). When the entire population was considered (133 patients and 120 volunteers), there was a significant correlation between MAPSE and LVEF (r =0.24, p<0.0001). There were no significant gender related differences in M/TAPSE among HCM patients or healthy volunteers. M/TAPSE did not significantly correlate with LV mass in HCM patients and did not differ in HOCM (MAPSE: 9±4 mm, TAPSE: 19±8 mm) compared to HNCM (MAPSE: 8±4 mm, TAPSE: 18±7 mm; p=ns). ANOVA analysis showed no significant differences in TAPSE, MAPSE or EF based on patients’ NYHA class. Among patients, there was a significant inverse correlation between MAPSE and NT proBNP (r= -0.29, p=0.004) as well as between TAPSE and NT proBNP(r= -0.20, p=0.046).
We provided reference values of M/TAPSE in a large cohort of HCM patients compared to a healthy study cohort. M/TAPSE were decreased in HCM compared to healthy volunteers and were not related to obstruction in HCM. The inverse relation to NT proBNP deserves further attention regarding a possible prognostic role of these measurements in HCM.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.