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- Open Access
Age and gender dependence of pre-contrast T1-relaxation times in normal human myocardium at 1.5T using ShMOLLI
© Piechnik et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Cardiovascular Magnetic Resonance
- Human Myocardium
- Myocardial Contour
- Oxford Biomedical Research
- Alberta Heritage Foundation
Robust pre-contrast reference T1 values using ShMOLLI in 231 normal human controls aged 11 to 81 years demonstrate little dependence on gender, age or heart rates.
Quantitative T1-mapping is rapidly becoming a clinical Cardiovascular Magnetic Resonance (CMR) imaging tool that can distinguish normal from diseased myocardium. The usefulness of any quantitative measurement to identify disease lies in its ability to detect significant differences from an established normal range of values. In this study we aim to establish a large database for the normal range of T1 values in healthy human myocardium and to examine any differences based on age and gender.
231 healthy volunteers underwent CMR with at least one ShMOLLI (Shortened Modified Look-Locker Inversion recovery) T1-map in one of three CMR centres. All data were acquired in 1.5T MR systems (Siemens, Avanto) using the ShMOLLI sequence for T1 maps as previously described [Piechnik at al. JCMR, 2010, 12:69] with 16 or 32 channel coil arrays. Each subject yielded a single average T1 value based on semi-automatically drawn myocardial contours in 3 short axis slices (typically, range 1-7, median=3, mean=3.3±1.1 slices). The heart rate (HR) was calculated from individual ShMOLLI image times.
Normal human myocardial T1 relaxation times can be measured precisely and show a narrow range of variation of about ±2% of the average in relation to age and gender but are not dependent on heart rate using ShMOLLI. T1 variability due to age and gender is small compared to the effect of major cardiac injuries, such as myocardial infarction which is characterised by 10-20% increase in T1. While normal variation will not impact on the sensitivity of T1-mapping to detect acute changes, for the detection of smaller T1 differences, age and gender matching between patients and controls may be desired.
SKP, VMF, MDR funded by the NIHR Oxford Biomedical Research Centre Programme. VMF funded by the Alberta Heritage Foundation for Medical Research (AHFMR) and the University of Oxford Clarendon Fund Scholarship. DS and SW funded by British Heart Fundation.
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