- Poster presentation
- Open Access
Application of high resolution T1 mapping with MOLLI (hrMOLLI) to differentiate patients with diffuse and regional myocardial disease from healthy subjects
© Pastor et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Cardiac Magnetic Resonance
- Late Gadolinium Enhancement
- Hypertrophic Cardiomyopathy
- Fibrotic Tissue
Cardiac magnetic resonance (CMR) is increasingly applied as the first line investigation into the causes of myocardial dysfunction and remodelling. Although regional fibrosis is easily imaged on late gadolinium enhancement, characterisation of myocardial conditions with diffuse fibrosis remains challenging. Several studies proposed T1 mapping of gadolinium-enhanced myocardium supported by an inverse relationship between T1 relaxation times and amount of fibrotic tissue on histology. We performed high-resolution modified Look-Locker inversion recovery (hrMOLLI) imaging of native and postcontast myocardium in thirty-six subjects who underwent a routine CMR protocol for investigation of cardiomyopathy.
Several studies proposed T1 mapping of gadolinium-enhanced myocardium supported by an inverse relationship between T1 relaxation times and amount of fibrotic tissue on histology. To date no studies characterised the T1 values in non-enhanced myocardium in conditions with diffuse and regional fibrosis, nor evaluated its relation to post-contrast T1 values consistently in a clinical setting.
We performed high-resolution modified Look-Locker inversion recovery (hrMOLLI) imaging of native and postcontrast myocardium in thirty-six subjects (age (mean±SD) 47 ± 7.4 years) who underwent a routine CMR protocol for investigation of cardiomyopathy (hypertrophic cardiomyopathy: n=6; longstanding hypertension: n=7, previous myocardial infarction: n=12). Eleven subjects referred for exclusion of arythmogenic right ventricular cardiomyopathy with normal CMR findings served as controls. Single breath-hold hrMOLLI was performed on a 3T clinical scanner in an equatorial short axis slice prior and at 10, 20 and 40 minutes following administration of 0.2 mmol/kg gadolinium-DTPA contrast. Imaging parameters were FOV 320x320; TR/TE 3.2/1.57 ms, flip angle 50°, interpolated voxel size 0.9x0.9x8mm, phase encoding steps n=166, trigger delay: 450 msec. T1 map values were obtained by placing the region of interest (ROI) within the septal myocardium. In patients with myocardial scar on late gadolinium enhancement, ROIs were derived from both remote and scarred areas pre-contrast and 20 minutes afterwards only. In addition to the native and postcontrast T1 values the ratio between postcontrast and precontrast values was calculated.
We demonstrate that T1 mapping of native and postcontrast myocardium can serve to differentiate between healthy myocardium and diffuse fibrosis with better accuracy than after contrast injection.
NIHR British Research Centre.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.