Intravoxel Incoherent Motion applied to Cardiac diffusion weighted MRI using breath-hold acquisitions in healthy volunteers
© Delattre et al; licensee BioMed Central Ltd. 2012
Published: 1 February 2012
Diffusion weighted imaging (DWI) gives rise to a unique method to evaluate perfusion and diffusion parameters of a tissue without the need of any contrast agent, with the introduction of the Intravoxel Incoherent Motion (IVIM) model (Le Bihan, Radiology 1988). Despite its relevance, cardiac DWI has so far been limited to low b-values primarily due to signal loss induced by physiological motion. Recently, an efficient cardiac DWI method was proposed where images were acquired at different time points of the cardiac cycle and where motion-induced signal-loss was removed by Principal Component Analysis (PCA) filtering and temporal MIP (tMIP) techniques (PCATMIP) (Rapacchi, Invest Radiol 2011). We compared the IVIM parameters obtained at a single optimized diastolic time point of the cardiac cycle (1TD) to the results obtained with PCATMIP technique.
Breath-hold DWI scans were performed on 12 volunteers for 10 trigger-delay values in diastole. 13 b-values ranged from 0 to 550 s/mm2 were used. Signal intensity (SI) of the LV myocardium was fitted with the IVIM model corrected for T1/T2 relaxation (Lemke, MRM 2010).
This study demonstrates feasibility and reports for the first time cardiac IVIM parameters in normal humans. PCATMIP minimized the motion-induced signal loss which is the main problem in cardiac DWI. This study opens new perspectives for perfusion imaging without contrast media.
This work was supported by the French National Agency for Research (ANR).
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