- Poster presentation
- Open Access
Phase sensitive inversion recovery with simultaneous dark fat rendering by virtual chemical inversion
© Jenista et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Readout Time
- Phase Sensitive Inversion Recovery
- Selective Inversion
- Selective Saturation
- Virtual Chemical
On delayed-enhancement (DE-CMR), both fat and infarcted myocardium appear bright making them difficult to differentiate. Standard chemical shift fat-suppression (FatSatCS) consists of a fat-frequency selective saturation followed by readout. This approach is suboptimal in clinical DE-CMR sequences which typically have long readout times (100-200ms) and as a result, fat magnetization has significantly recovered (T1 = 290ms, 3T) when the center of k-space is acquired for linear reordering. Centric reordering can overcome this limitation, but at the cost of blurring artifacts.
The phase sensitive inversion recovery (PSIR) variant of DE-CMR avoids the need to precisely set inversion time through the acquisition of a reference data set interleaved between image acquisitions. We hypothesized that modifying the reference acquisition via a Dixon-type approach could provide PSIR images that simultaneously show dark fat without added acquisition time. The result is a virtual chemically selective inversion (FatSatVCSI), without increased SAR and at no cost to signal-to-noise from pulse imperfections.
DE-CMR images in phantoms and patients (n=7) were acquired at 3T (Siemens) with a segmented gradient-echo readout. In phantoms, we studied the relationship of readout duration (by varying the number of lines per segment) to fat signal. FatSatCS efficacy was studied for both centric and linear reordering. In patients, three sequential PSIR images were acquired: no fat suppression, FatSatCS and the FatSatVCI with the same parameters including inversion time. Regions of interest (ROIs) were drawn in pericardial and subcutaneous fat and left ventricular blood pool. The performance of each technique was evaluated by comparing the fat-to-blood signal ratios.
By modifying the reference acquisition of a PSIR scan, we provide PSIR images with and without fat suppression in a single acquisition. No additional data acquisition, RF pulses, or increased scan time is required.
NIH grant 5R01HL064726-07.
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