- Poster presentation
- Open Access
Improved fat water separation with water selective inversion pulse for inversion recovery-based cardiac MRI sequence
© Havla et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Late Gadolinium Enhancement
- Fatty Infiltration
- Arrhythmogenic Right Ventricular Cardiomyopathy
- Inversion Pulse
- Separate Scan
Chemical shift based water-fat separation methods can be used to reconstruct simultaneous fat and water images, thereby improving the sensitivity of fat detection using a positive fat contrast. The presence of fatty infiltration is a hallmark pathological feature of arrhythmogenic right ventricular cardiomyopathy (ARVC). Furthermore, the presence of fatty infiltration in chronic myocardial infarction has been demonstrated recently [1, 2]. To assess for both presence of scar using late gadolinium enhancement (LGE) and fat, two separate scans are needed. In this study, we propose an improved inversion recovery based water-fat separation sequence in which the fat signal is retained by the application of a spectrally selective water inversion pulse, thereby eliminating the need for two separate scans.
A free-breathing 3D LGE sequence with multi-echo gradient echo imaging sequence and a water-selective inversion pulse was implemented on 1.5T Philips Achieva system. To evaluate the efficacy of the proposed sequence, imaging in phantom were performed. The phantom contains multiple vials with different T1s and a vegetable oil vial. Subsequently, fat-water separation was performed in 8 patients referred for evaluation of ARVC. The 3-echo 3D GRE sequences are respiratory navigator-gated (acceptance windows 5mm) and ECG-triggered with in-plane spatial resolution of 1.5x1.2mm2 and slice thickness 2.0 or 4.0mm. TR/TE1/TE2/TE3/α= 8.0/1.5/4.0/6.5/15°, FOV= 300x300x100mm3. The IDEAL with a region growing technique [3, 4] was used to reconstruct separate water and fat images.
The water-selective inversion pulse significantly improves visualization of the fat signal in inversion-recovery based water-fat separation, thereby allowing the assessment of water and fat content and fibrosis/scar using LGE in a single scan.
The authors acknowledge grant support from NIH R01EB008743-01A2. Lukas Havla was supported by a fellowship from Bayer Science & Education Foundation.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.