- Poster presentation
- Open Access
T2 relaxation time mapping in phantom and in vivo myocardial studies to investigate optimal method of quantification
© Vernikouskaya et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Phantom Data
- Slice Thickness 10mm
- Respective Quantification
- Single Breathhold
- Parallel Imaging Acceleration
Reproducible and accurate T2 measurements are required for the characterization of myocardial tissue, e.g. to distinguish healthy, scar and edematous myocardium. It is the objective of this study to investigate the impact of the fitting algorithm applied for the T2 quantification from data derived from a single-breathhold T2-prepared steady-state free precession (T2p-SSFP) imaging technique.
In direct comparison to multi spin echo technique, superior performance of T2p-SSFP-based T2 quantification has been reported. In spite of availability of a variety of quantification algorithms, the use of mono-exponential model is still the standard for fitting the T2 decay curve.
All data were acquired on 1.5T clinical whole-body scanner. The Eurospin Test Object TO5 Contrast phantom was used for initial validation of the T2p-SSFP technique and comparison of accuracy of investigated models. Phantom data were acquired with 9 different T2 preparation times (TE from 0 to 150ms). Acquisition parameters: matrix 240x240, slice thickness 5mm, FOV 2302mm2, TR/TE 4.4/2.2ms, flip angle 60°.
The phantom data (Fig. 2e) revealed that the offset model performs best for fitting the data. A non significant (p = 0.35) deviation from the recorded T2 values was observed, whereas mono-exponential (p = 0.0027) and numerical (p = 0.00038) models significantly overestimate the data. In vivo measurements showed a significant (p = 0.003) reduction in the calculated T2 value for the offset model. T2-mapping applying the offset model yields a mean T2 value of 33.7ms (Fig. 2d) vs 41.6ms (Fig. 2c) and 40.9ms (Fig. 2b) for the mono-exponential and numerical models.
The phantom data showed superior performance of the offset model for T2 quantification as compared to the mono-exponential and numerical model for T2p-SSFP. The respective quantification of myocardial T2 values in vivo yielded a lower value as previously reported. This may indicate that applying simple mono-exponential decay model may overestimate resulting T2 value in myocardium.
EU FP7 REBORNE
Project Reference 241879.
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