Hemorrhagic myocardial infarction: detection using susceptibility weighted phase imaging
© Goldfarb et al; licensee BioMed Central Ltd. 2012
Published: 1 February 2012
In this study we determined the normal range of high-pass filtered image phase values in a group of normal subjects for all sixteen segments of the heart. The range and standard deviations varied significantly across the heart, with less variance in septal segments. In a group of acute myocardial infarction patients, phase values in hemorrhagic myocardial infarction were significantly less than normal segments and well depicted as hypointense lesions in filtered-phase images.
Myocardial hemorrhage in patients with acute myocardial infarction (AMI) is a form of severe reperfusion injury. Detection has been shown with T2-weighted (T2W) and T2*-weighted magnitude images and is closely associated with microvascular obstruction (MVO). Limitations of the T2W technique include the prerequisite of myocardial edema as well as adequate visualization of myocardial edema to detect a hypointense infarct core. Overall quality of T2*-weighted images across all segments of the myocardium limits its usage for evaluation of the entire left ventricle. Susceptibility-weighted phase images have been shown to be sensitive for the detection of hemosiderin in microbleeds of the brain and should be an effective means of detecting myocardial hemorrhage.
15 healthy control subjects and 11 AMI patients were studied at 1.5 T. The comprehensive study protocol included cine, T2-weighted, T2*-weighted, resting perfusion and late gadolinium-enhanced imaging. High-pass filtered phase images were reconstructed from breath-hold multi-echo T2*-weighted acquisitions (Echo delay time(TE) =2.4-15.5ms, 2.2ms spacing) over the entire left ventricle. ROIs were drawn for each subject in each of the 16 AHA myocardial segments and the mean phase and standard deviation were recorded. Normal variations in myocardial phase across echo delay time and anatomical segment were compared in the control group using ANOVA and normal ranges as mean+-2*standard deviations were calculated. Analysis of the phase measured with the same control group protocol across echo times in AMI patients was plotted and compared to normal ranges.
High pass filtered myocardial phase is small and normally varies by anatomical myocardial segment and echo delay time. Myocardial hemorrhage causes a significant phase decrease beyond these normal variations. High-pass filtered phase imaging represents a quantitative, high quality method for the detection of myocardial hemorrhage without the need for the presence or high quality visualization of myocardial edema.
American Heart Association Scientist Development Grant, 0635029N.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.