- Poster presentation
- Open Access
Highly accelerated cardiac functional MRI in rodent hearts using compressed sensing and parallel imaging at 9.4T
© Wech et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Compressed Sensing
- Parallel Image
- Acceleration Factor
- Good Image Quality
- Acceleration Technique
Parallel Imaging and Compressed Sensing have individually been shown to speed up cardiac functional MRI in mice and rats at ultra-high magnetic fields whilst providing accurate measurement of the physiologically relevant parameters. This study demonstrates that the acquisition time for cine-MRI in rodent hearts can be significantly reduced further by combining both techniques.
Parallel Imaging (PI) and Compressed Sensing (CS) are alternative approaches to reduce scan time in Magnetic Resonance Imaging (MRI). Specifically, PI (i.e. TGRAPPA) has recently been demonstrated to provide a three- to four-fold acceleration of cine-MRI in mice and rats (Schneider et al, MRM 2008 & 2011), while CS allowed for a three-fold reduction in scan time in normal mice and in a murine model of chronic myocardial infarction (Wech et al, JMRI 2011). In both cases, the increase in speed was achieved without impacting on the accuracy and reproducibility of cardiac functional parameters. We now hypothesized that PI and CS combined will allow to even further accelerate cine-MRI in rodent models of cardiovascular disease.
All experiments were conducted on a horizontal, 9.4T MR system (Agilent) equipped with 8 receive-channels. Fully sampled cine-data were obtained in rats and mice, using a 2D multi-frame GE-sequence, and a 4-channel cardiac array and an 8-channel probehead, respectively. Matrix size (256 x 256) and temporal resolution (TR = 4.6ms) were identical for both cases. The fully acquired cine-data sets were retrospectively undersampled and subjected to two consecutive image reconstruction steps: first, a CS-algorithm reproducing k-t-SPARSE by Lustig et al (ISMRM 2006) was utilized to generate a moderately undersampled k-space. Subsequently, GRAPPA (Griswold et al, MRM 2002) was applied to obtain fully sampled cine-data.
Our data suggest that PI and CS combined will significantly reduce acquisition time down to the minute-range for cardiac functional MRI in rodents. Work is in progress to validate this technique quantitatively, and to determine the optimal combination of both acceleration techniques.
This work was funded by the British Heart Foundation and the Elite Network of Bavaria.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.