- Poster presentation
- Open Access
Analysis of the septal curvature with CMR in the paediatric population with pulmonary hypertension is a useful tool
© Pandya et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Pulmonary Hypertension
- Pulmonary Vascular Resistance
- Short Axis Image
- Ventricular Free Wall
- Established Disease
Paediatric pulmonary hypertension is often difficult to assess non-invasively. Early detection and treatment of mild disease in high-risk populations e.g. pulmonary disease is associated with improved outcome. In such cases, echocardiographic measurement of tricuspid regurgitation is unreliable for estimation of right heart pressure. Cardiac MR imaging offers an alternative, using deformation of the interventricular septum to assess the pressure differential between the ventricles. In this study, we hypothesised that this technique offers a useful tool for both detection of pulmonary hypertension and assessment of those with established disease.
This study shows that SCR is a sensitive tool for differentiating normal PVR from those with pulmonary hypertension in the paediatric population. Our approach took advantage of real-time kt-SENSE imaging of the ventricular short axis to reduce apnoea under anaesthesia in MR/catheter procedures. In routine MR, this sequence should make SCR measurement feasible in a wide age range of unsedated children, where scanning must often be rapid. SCR measurement in children is quick to perform and both sensitive and specific at identifying even mild disease. It was also noted that although there were strong correlations between SCR and measures of PAP and PVR, diagnostic differentiation was poor in established disease.
BP/VM funded by The British Heart Foundation.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.