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- Open Access
Severity of mitral valve prolapse is associated with basal left ventricular hypertrophy: a cardiac magnetic resonance study
© Zia et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Cardiac Magnetic Resonance
- Hypertrophic Cardiomyopathy
- Mitral Valve Prolapse
- Mitral Valve Annulus
- Cardiac Magnetic Resonance Study
Mitral valve prolapse (MVP) is associated with concentric basal hypertrophy of the left ventricle. We found a strong correlation between the excursion of the mitral valve annulus and the degree of relative hypertrophy suggesting the possibility that locally increased myocardial function may be responsible for the hypertrophy.
Our objective was to characterize the extent and distribution of focal basal left ventricular hypertrophy in patients with MVP and assess the correlation between the degree of focal hypertrophy and various myocardial structural parameters.
Sixty-two patients (mean age: 58 years +/- 14; 56% males) with MVP and 20 age-matched normal volunteers (mean age: 53 years +/- 11; 50% males) were assessed using cardiac magnetic resonance imaging. We compared the ratio of basal to mid end-diastolic wall thickness in both groups and correlated it with various parameters such as age, left ventricular dimensions, degree of prolapse, mitral regurgitation volume, and mitral annular excursion.
MVP is associated with concentric basal hypertrophy of the left ventricle. A moderate correlation between the excursion of the mitral valve annulus and the degree of relative hypertrophy suggests the possibility that locally increased myocardial function may be responsible for the hypertrophy. It is important to consider this mechanism when evaluating patients with basal hypertrophy to exclude the incorrect diagnosis of hypertrophic cardiomyopathy.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.