Volume 14 Supplement 1
Retrogated spiral 3-directional myocardial phase velocity mapping in a single breath-hold
© Simpson et al; licensee BioMed Central Ltd. 2012
Published: 1 February 2012
Myocardial phase velocity mapping studies have generally been acquired using Cartesian k-space coverage and respiratory gating [1, 2]. Acquisition durations for high temporal resolution studies are therefore long and unpredictable and the use of navigators and prospective cardiac gating results in ‘dead-times’ in the cardiac cycle where imaging cannot be performed. We have developed a technique which combines highly efficient spiral k-space coverage with retrospective cardiac gating for 3D velocity mapping over the entire cardiac cycle within a breath-hold. The feasibility for rapid assessment of myocardial motion is demonstrated.
The sequence (TR=30ms) consists of five interleaved spiral k-space paths (23ms). Reference and 3-directional velocity encoded data (15cm/s in-plane, 25cm/s through-plane) are acquired in consecutive cardiac cycles following a single dummy cycle (breath-hold duration 21 cardiac cycles). A black-blood suppression pulse (6ms) is output on alternate phases to reduce blood flow artefacts and retrospective gating allows full coverage of the cardiac cycle. Forty phases are reconstructed (reconstructed temporal resolution 19-31ms depending on heartrate) with an acquired spatial resolution of 2.4 x 2.4 x 8mm (reconstructed 1.2x1.2mm).Basal, mid and apical short axis slices were acquired in 6 healthy volunteers on a Siemens Skyra 3Tesla scanner. Radial, circumferential and longitudinal velocities were calculated pixel-wise and as an average over six semi-automatically segmented regions of the left ventricle.
We have developed a phase velocity mapping technique which allows 3D myocardial velocities to be acquired in a single breath-hold. The spiral k-space coverage results in reasonable temporal resolution (33ms) and the implementation of retrospective ECG-gating allows analysis of the entire cardiac cycle, including atrial contraction. Future work will include implementing an on-line correction map to reduce off-resonance blurring and parallel imaging to reduce the breath-hold duration.
Heart Research UK grant:RG2584.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.