- Workshop presentation
- Open Access
Early diastolic function observed in canine model of reperfused transmural myocardial infarction using high temporal resolution MR imaging
© Zhang et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Diastolic Function
- Late Gadolinium Enhancement
- Infarct Region
- Late Gadolinium Enhancement Imaging
- Mitral Inflow Velocity
We have applied a novel high temporal resolution MR imaging sequence to study diastolic function in canines with reperfused transmural infarction. Our results demonstrate abnormal diastolic strain-rates in infarct and viable risk region with corresponding abnormal filling patterns, as observed through the visualization of 2D flow pathlines 3 days post reperfusion.
Coronary angioplasty limits infarct expansion post myocardial infarction (MI). However, under certain conditions such as prolonged ischemia, the procedure induces reperfusion injury (RI), linked to adverse left ventricular (LV) remodeling and heart failure (HF). The functional mechanisms involved in adverse remodeling post reperfusion are still unclear. We have developed a new high temporal resolution MR imaging technique, SPAMM-PAV (SPAtially Modulated Magnetization with Polarity Alternated Velocity encoding) that provides regional assessment of early diastolic flow velocity and myocardial strain. This method was applied in a canine animal model with prolonged occlusion followed by reperfusion. We examine the diastolic strain-rates (index of stiffness) of infarct regions relative to remote regions and the 2D diastolic flow pathlines 3 days post reperfusion to provide insight into early diastolic function in these animals.
In conclusion, in a canine model of reperfused transmural infarction we observe decreased diastolic strain-rates in the infarct and viable risk regions relative to remote regions and corresponding abnormalities in diastolic filling patterns at 3 days post reperfusion.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.