Myocardial fibrosis with T1 mapping and right ventricular performance in pulmonary hypertension
© Garcia-Lunar et al; licensee BioMed Central Ltd. 2013
Published: 30 January 2013
Pulmonary hypertension (PH) leads to progressive right ventricular (RV) dilatation, hypertrophy, and systolic dysfunction. PH is also associated with the presence of late gadolinium enhancement in the interventricular septum (IVS). Post-contrast T1 mapping is a previously validated non-invasive technique for the quantification of extracellular volume increase as a surrogate of diffuse interstitial fibrosis. The aim of our study was to evaluate the presence of septal fibrosis in PH patients with T1 mapping, and to investigate potential correlations with RV performance and hemodynamic status.
24 patients with known or suspected PH of various etiologies (excluding left heart disease) were included in the study. Cardiac magnetic resonance (CMR) was performed on a 3-T scanner and the IVS T1 time was quantified offline by an independent and blinded observer on a Look-Locker sequence acquired 5-15 minutes after the infusion of 0.19±0.03 mmol/kg of gadopentetate dimeglumine. End-diastolic RV free wall thickness was measured on a cine sequence at the left ventricular outflow tract view. Twenty (83%) patients additionally underwent right heart catheterization. Using Pearson r coefficients, septal T1 times were correlated with RV volumes and ejection fraction as derived from CMR, and cardiac output and pulmonary pressures and vascular resistance obtained invasively.
Correlation of IVS T1 time with CMR and right heart catheterization measurements.
RV wall thickness
A reduction in post-contrast T1 times in the IVS, possibly indicating increased interstitial fibrosis, correlates with RV structural and functional impairment and hemodynamic severity in PH. T1-mapping may constitute a novel approach for the evaluation of cardiac adaptation to pressure overload.
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