- Poster presentation
- Open Access
Non-invasive measurement of myocardial extracellular volume using T1 mapping as a novel biomarker of diffuse fibrosis in dilated cardiomyopathy
© aus dem Siepen et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Cardiac Magnetic Resonance
- Diffuse Fibrosis
- Late Gadolinium Enhance
- Diffuse Myocardial Fibrosis
- Extracellular Volume Fraction
Diffuse myocardial fibrosis is frequently observed in histologies of dilated cardiomyopathy (DCM). T1-mapping techniques have the potential to measure fibrosis quantitatively and therefore provide novel cardiac magnetic resonance (CMR) insights into myocardial tissue characterization beyond the presently employed late gadolinium enhanced (LGE) techniques. Fibrosis results in expansion of the myocardial extracellular volume fraction (ECV). Recent reports indicate that T1-mapping calibrated by the blood hematocrit is a promising tool to non-invasively quantify ECV. We explored the clinical utility of this technique in a DCM cohort with different disease stages.
Extracellular volume fraction as quantified by T1 mapping CMR is enlarged in DCM reflecting diffuse myocardial fibrosis, which is present even in milder disease forms. In contrast to conventional T1 mapping , ECV fraction measurement quantifies diffuse fibrosis in absolute, easy to understand units making it easier to follow up patients or to compare the amount of fibrosis in different patients' groups.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.