Skip to main content

Assessment of diffuse myocardial fibrosis in systemic sclerosis by cardiac magnetic resonance imaging


Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive fibrosis of the skin and internal organs, including the heart. Traditional late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) imaging is dependent on differential (i.e., focal) fibrosis within the myocardium. However, diffuse interstitial myocardial fibrosis (DF) affecting the entire myocardium may be missed because no normal reference region exists. T1 mapping has been utilized in a variety of techniques to assess diffuse fibrosis: 1) pre-contrast T1 measurement (PreT1), 2) post-contrast T1 measurement (PostT1), 3) partition coefficient (PC), and 4) volume of distribution (VD). We sought to evaluate the accuracy of LGE and various T1 mapping techniques for the assessment of myocardial fibrosis in patients with SSc.


CMR was performed in 13 SSc patients (5 diffuse and 8 limited cutaneous) and 13 age-matched controls. Cine, pre- and post-contrast T1 mapping, and late gadolinium enhanced (LGE) imaging was performed. Calculation of PC and VD were: PC = ΔR1myocardium/ΔR1bloodpool. VD = [ΔR1myocardium/ΔR1bloodpool × p × (1 - hematocrit)] - Vp, where R1 = 1/ T1, ΔR1 is post-contrast - pre-contrast R1, p is myocardial specific density (1.05), and Vp is myocardial plasma volume fraction (0.045). The modified Rodnan skin score (mRSS), a measure of SSc disease activity, was quantified in all SSc patients by clinicians blinded to all CMR data.


There was no visible LGE in 10/13 SSc and 13/13 controls. VD was significantly higher in SSc than controls (27.4 ± 4.6% vs. 20.6 ± 3.3%, p = 0.0003), even when patients with visible LGE were excluded (26.9 ±4.0% vs. 20.6 ± 3.3%, p = 0.001). PreT1, PC, and VD all correlated significantly with log mRSS in SSc patients, the correlation for PostT1 was not significant (Figure 1 and Table 1). Comparison of correlation coefficients demonstrates VD > PreT1 > PD > PostT1.

Figure 1
figure 1

Scatter plots for CMR measures of diffuse fibrosis versus scleroderma severity by mRSS

Table 1 Correlation with Systemic Sclerosis Severity by mRSS


This is the first study to compare various T1 mapping techniques for the assessment of diffuse interstitial myocardial fibrosis in patients with SSc. PreT1 provides a surprisingly good assessment of DF in SSc, and may be useful in patients with impaired renal function. Calculation of VD - which requires measurement of hematocrit, PreT1, and PostT1 - is more time consuming but provides the most accurate assessment of DF in SSc. Calculation of PC and PostT1 - which allow one to eliminate hematocrit or hematocrit and PreT1, respectively - provide simpler but less accurate measures of DF in SSc.



Author information

Authors and Affiliations


Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Lee, D.C., Sarnari, R., Benefield, B. et al. Assessment of diffuse myocardial fibrosis in systemic sclerosis by cardiac magnetic resonance imaging. J Cardiovasc Magn Reson 15, E121 (2013).

Download citation

  • Published:

  • DOI:


  • Partition Coefficient
  • Cardiovascular Magnetic Resonance
  • Late Gadolinium Enhancement
  • Systemic Sclerosis
  • Late Gadolinium Enhance