- Poster presentation
- Open Access
Assessment of myocardial and LV blood pool post-contrast T1 evolution: comparison between healthy subjects and patients with hypertrophic cardiomyopathy
© Kachenoura et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Hypertrophic Cardiomyopathy
- Short Axis Slice
- Myocardial Wall Thickness
- Interstitial Myocardial Fibrosis
- Post Contrast Acquisition
The choice of post contrast acquisition time is crucial to optimize T1 mapping. Indeed, equilibrium is required for a reliable characterization of interstitial myocardial fibrosis. The majority of studies regarding T1 equilibrium were performed on healthy subjects. Accordingly, the aims of our study were 1) to assess post-contrast T1 Kinetics in HCM patients, in comparison to healthy volunteers, and 2) to determine acquisition times that enable a better differentiation between the two groups.
We studies 14 HCM patients (10 males, age:58±12 years, myocardial wall thickness=12±4 mm, Heart rate=61±9 bpm), diagnosed by echocardiography, and 9 healthy volunteers (4 males, age:33±16 years, myocardial wall thickness=5±1 mm, Heart rate=71±10 bpm). Patients with arrhythmia or renal failure were excluded. Modified Look-Locker Inversion Recovery (MOLLI) sequences were acquired on a mid-ventricular short axis slice before contrast and every 5 minutes after a bolus injection (0.2 mmol/Kg, Dotarem) over 20 minutes. Segmental T1 values were calculated after myocardial delineation on each T1 map. Furthermore, presence of LGE was assessed visually in 20 segments from 2D LGE images.
While differences in myocardial T1 values were found to be highly significant between HCM and controls pre contrast and at 5 and 20 minutes after injection, no significant differences were found at 15 minutes. Accordingly, tailored acquisition times may be necessary for the characterization of myocardial interstitial fibrosis in differing conditions.
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