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Cardiac magnetic resonance myocardial feature-tracking: the effect of treatment in patients with adult-onset growth hormone deficiency and acromegaly

Background

We have previously documented abnormalities in cardiac structure in patients with adult-onset growth hormone deficiency (GHD) and acromegaly which partially resolved during treatment (Dattani et al. 2012, Zemrak et al. 2012).

No treatment effect was seen on global measures of cardiac function e.g. left ventricular ejection fraction.

The aim of this study was to use quantitative strain parameters from cardiac magnetic resonance (CMR) myocardial feature tracking (FT) to assess regional changes in function before and after treatment in patients with GHD and acromegaly.

Methods

10 patients with GHD, 13 patients with acromegaly and 23 age- and sex-matched normal controls underwent CMR. Patients underwent scanning before and again 12 months after treatment. Radial and circumferential strain parameters were derived from 2-chamber (2CH), 4-chamber (4CH) and basal, mid and apical short axis cine-images using dedicated FT software (Diogenes MRI, TomTec Imaging Systems, Munich, Germany). Comparisons between groups were performed using the T-test.

Results

There were no significant differences in any FT derived parameters between normal controls and patients with GHD.

There was a significant difference in 4CH-circumferential strain in patients with acromegaly compared to normal controls (-7.6% vs -5.0%, p=0.01). There were no significant differences in the remaining parameters.

The effect of treatment on FT derived indices is shown in Tables 1 and 2.

Table 1 The effect on feature-tracking parameters before and after one year of treatment in acromegaly patients.
Table 2 The effect on feature-tracking parameters before and after one year of treatment in GHD patients.

Conclusions

Other than 4-CH circumferential strain, no differences were seen in any FT derived strain measurements between patients with GHD and normal controls, patients with acromegaly and normal controls and following 12 months of treatment.

The structural changes seen in patients with acromegaly and GHD deficiency may, therefore, precede significant functional abnormalities. Early identification and treatment of these patients may prevent the development of functionally important myocardial damage.

Funding

This study has been supported by departmental grants from NIHR, Pfizer and Novartis.

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Correspondence to Mahvesh R Javaid.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Javaid, M.R., Stone, I.S., Grossman, A.B. et al. Cardiac magnetic resonance myocardial feature-tracking: the effect of treatment in patients with adult-onset growth hormone deficiency and acromegaly. J Cardiovasc Magn Reson 15, E55 (2013). https://doi.org/10.1186/1532-429X-15-S1-E55

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Keywords

  • Normal Control
  • Cardiac Magnetic Resonance
  • Acromegaly
  • Strain Measurement
  • Growth Hormone Deficiency