- Poster presentation
- Open Access
Aortic wall gadolinium enhancement in thoracic aortic aneurysm patients
© Shiran et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Connective Tissue Disease
- Aortic Wall
- Marfan Syndrome
- Thoracic Aortic Aneurysm
- Tissue Blood Flow
Thoracic aortic aneurysm (TAA) disease is an often asymptomatic, insidious process that includes structural aortic changes, dilation, and eventually causes death. Aneurysm prevalence exceeds 4% and is the 15th leading cause of death in the US. TAA disease is associated with congenital and acquired defects in the aortic wall including elastin derangements, increased collagen, glycosaminolycan/proteoglycan accumulation, and loss of smooth muscle cells. We aim to investigate these changes non-invasively by studying the uptake of gadolinium (Gd) in the diseased aortic wall. The distribution and accumulation of Gd depends on tissue blood flow, the size of the interstitial space, and permeability of capillaries, and has potential to help characterize severity of TAA disease.
Significant aortic wall Gd enhancement is seen in patients with connective tissue diseases and aneurysm formation and likely represents presence and severity of underlying tissue pathology.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.