- Poster presentation
- Open Access
High spatial and temporal resolution dynamic contrast-enhanced magnetic resonance angiography (CE-MRA) using compressed sensing with magnitude image subtraction
© Rapacchi et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Image Acquisition Speed
- Complex Subtraction
- Base Reconstruction Algorithm
- MDCS Image
- Magnitude Subtraction
Due to limitations in image acquisition speed, dynamic CE-MRA typically has lower spatial resolution than conventional CE-MRA. In a breath-held dynamic CE-MRA acquisition, the subtraction of a pre-contrast mask to all post-contrast frames promotes sparsity of the resulting difference images. This "subtraction sparsity" using direct k-space complex subtraction has previously been shown to benefit parallel imaging as well as compressed sensing but suffers from SNR loss. We propose a novel CS algorithm for dynamic CE-MRA that integrates magnitude subtraction into the reconstruction to avoid direct complex subtraction while taking advantages of the "subtraction sparsity".
The reconstruction uses a split-Bregman minimization of the sum of the L1 norm of the pixel-wise magnitude difference between two successive temporal frames, i.e. |(|I_2 |-|I_1 |)|_1, a fidelity term and a total variation (TV) sparsity term.
Retrospective study: a full-sampled Cartesian 3D GRE sequence was used for the CE-MRA acquisitions on 6 volunteers with a resolution of 1x1x1.3-2.2 mm3. Datasets were retrospectively subsampled and different strategies of reconstruction were quantitatively and qualitatively evaluated: a) magnitude subtraction of the original k-space images; b) separate independent CS reconstructions (IDCS); c) k-space complex subtraction CS reconstruction (KDCS); d) magnitude subtraction CS reconstruction (MDCS).
Prospective study: a sequence was implemented that is capable of prospectively acquire under-sampled 3D dynamic CE-MRA data according to pre-defined sampling mask at 1x1x2.0 mm3 resolution. The net acceleration from random subsampling was set to 12-fold, enabling the acquisition of 6 volumes within a single breath-hold on 2 volunteers.
CS-accelerated MRA has the potential to benefit MRA clinical practice. The extension of our algorithm with parallel imaging remains to be explored. The concept of magnitude subtraction can also be extended to many applications like dynamic contrast-enhanced MRI for perfusion imaging.
The authors acknowledge research-funding support from American Heart Association (10SDG4200076), National Institutes of Health (1R21HL113427) and Siemens Healthcare.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.