- Poster presentation
- Open Access
Highly accelerated single breath-hold non-contrast thoracic MRA: evaluation in a clinical population
© Lim et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Image Quality
- Thoracic Aorta
- Steady State Free Precession
- Diagnostic Confidence
- Left Main
Gadolinium enhanced MRA (Gd-MRA) is commonly used in clinical practice for evaluation of the thoracic aorta. Electrocardiographic (ECG) gating is required for accurate aortic root assessment, but decreases scanning efficiency. We evaluate the performance of a highly accelerated, breath-hold 3D ECG-gated non-contrast enhanced steady state free precession MRA technique (NC-MRA) in a clinical population, compared with ECG-gated Gd-MRA.
30 patients (22 male, mean age 53.4 years) with known or suspected thoracic aortic pathology were imaged with NC-MRA followed by Gd-MRA at 1.5T following informed consent. Images were anonymized and reviewed by 2 readers for aortic pathology. Diagnostic confidence, image quality and artifacts were evaluated on a 5-point Likert scale (1=worst, 5=best), with image quality and artifacts evaluated segmentally in 10 vascular segments, including the sinuses of Valsalva and coronary artery origins. Aortic dimensions were measured in 7 aortic segments. Diagnostic confidence, image quality and artefact scores were evaluated with the Wilcoxon signed rank test. Paired Student t-test and Bland-Altman analysis were used for comparison of aortic dimensions.
Breath-hold non-contrast enhanced MRA of the thoracic aorta yields good image quality, comparable to ECG-gated gadolinium-enhanced MRA, with high accuracy for aortic dimensions and pathology. It can be considered an alternative to gadolinium-enhanced MRA in patients with relative contra-indications to gadolinium contrast or problematic venous access.
This project was supported by grant number K12HS019473 from the Agency for Healthcare Research and Quality. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Agency for Healthcare Research and Quality. D.K.S. and J.X. receive grant support from National Institutes of Health R01-DK069373. J.X. is an employee of Siemens Medical Solutions.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.