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- Open Access
CINE-MRI to study the progress of disease in a chronic atrial fibrillation goat model
© Werys et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Atrial Fibrillation
- Ejection Fraction
- Left Ventricle
- Left Atrium
- Atrial Pace
Atrial fibrillation (AF) is a common sustained cardiac arrhythmia associated with increased risks of heart failure, left ventricle (LV) dysfunction, and known to cause an increase in left atrium (LA) volume with decrease in atrial contractility. Cine magnetic resonance images (MRI) were used to measure changes in LA and LV function in a chronic AF goat model. Ejection fraction (EF), end diastolic volume (EDV), end systolic volume (ESV), and stroke volume (SV) measurements of both the LV and LA were made from cine-MR images to track the progression of disease in goats that were induced with AF using neurostimulators.
We conclude cine-MRI is a useful tool to track the progress of disease in a chronic AF model. In the chronic AF goat model, computed atrial EF is more affected than the ventricular EF in the first 3 months after pacing (49% vs. 15%). Significant increase in LA volume was also observed following atrial pacing. Atrial pacing affects the volumes of both atrium and ventricle resulting in statistically significant increases of EDV and ESV after being paced for 3 months.
This project was supported in part by the Ben B. and Iris M. Margolis foundation. Mr. Werys is supported by a scholarship from the European Union in the framework of European Social Fund through the Warsaw University of Technology Development Program.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.