- Moderated poster presentation
- Open Access
Spatial heterogeneity of intracardiac 4D relative pressure fields during diastole
© Eriksson et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Left Ventricle
- Pressure Range
- Swedish Research Council
- Lower Pressure Area
- Left Ventricle Volume
Blood flow within the cardiovascular system is driven by pressure differences, where blood accelerates from higher to lower pressure areas. Invasive methods of pressure measurement, which are commonly applied to assessment of diastolic function, may not capture the heterogeneity of regional intracardiac pressure differences. We utilized pressure fields based on time-resolved 3D CMR data to investigate the timing and distribution of intracardiac pressure gradients in the left heart throughout diastole.
12 healthy subjects (5 female, age 47±17 y.o. (mean±sd)) underwent MRI examination (1.5T, Philips Achieva) where 4D velocity and morphological short (SA) and long axis bSSFP data were acquired. Acquisition parameters for the velocity sequence were: TE 3.7 ms, TR 6.3 ms, spatial resolution 3x3x3 mm3, and k-space segmentation factor 2. This resulted in a temporal resolution of 50.4 ms. The field-of-view was adjusted to fit each subject.
This CMR study implies that intracardiac pressure gradients are spatially heterogenous during the diastolic phase. These results emphasize the benefit of pressure assessment from methods that take into account the 3D nature of the intracardiac pressure field. These findings may also impact the interpretation of clinical catheter-based intracardiac pressure measurements.
This study was funded by the Swedish heart-lung foundation and the Swedish research council.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.