Spatial heterogeneity of intracardiac 4D relative pressure fields during diastole
© Eriksson et al; licensee BioMed Central Ltd. 2013
Published: 30 January 2013
Blood flow within the cardiovascular system is driven by pressure differences, where blood accelerates from higher to lower pressure areas. Invasive methods of pressure measurement, which are commonly applied to assessment of diastolic function, may not capture the heterogeneity of regional intracardiac pressure differences. We utilized pressure fields based on time-resolved 3D CMR data to investigate the timing and distribution of intracardiac pressure gradients in the left heart throughout diastole.
12 healthy subjects (5 female, age 47±17 y.o. (mean±sd)) underwent MRI examination (1.5T, Philips Achieva) where 4D velocity and morphological short (SA) and long axis bSSFP data were acquired. Acquisition parameters for the velocity sequence were: TE 3.7 ms, TR 6.3 ms, spatial resolution 3x3x3 mm3, and k-space segmentation factor 2. This resulted in a temporal resolution of 50.4 ms. The field-of-view was adjusted to fit each subject.
This CMR study implies that intracardiac pressure gradients are spatially heterogenous during the diastolic phase. These results emphasize the benefit of pressure assessment from methods that take into account the 3D nature of the intracardiac pressure field. These findings may also impact the interpretation of clinical catheter-based intracardiac pressure measurements.
This study was funded by the Swedish heart-lung foundation and the Swedish research council.
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