- Moderated poster presentation
- Open Access
Evolution of aortic wall thickness: long-term follow up from the Multi-Ethnic Study of Atherosclerosis (MESA)
© Liu et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Thickened Intima
- Average Yearly Rate
- Human Artery
- Electronic Caliper
- Double Inversion Recovery
A number of studies have been published over the years concerning the relationship between the thickened intima of human arteries and atherogenesis. Increased arterial wall thickness is associated with the prevalence and incidence of cardiovascular disease. Age-related increases of aortic wall thickness have been reported in several cross-sectional community-based studies. However, longitudinal changes of these measurements have not yet been documented. The purpose of this study is to characterize age- and sex-specific aortic wall thickness (AWT) distributions and yearly rates of change in older adults.
371 longitudinal and 426 cross sectional studies with AWT images by MRI were analyzed. MRI was performed at first in MESA1 (baseline, 2000-2001), and then in MESA5 (ten-year follow-up, 2010-2011). Both exams used 1.5-T whole-body MRI systems. Images were obtained using a double inversion recovery black-blood fast spin-echo sequence with ECG gating. Axial images of the descending thoracic aorta were obtained at the level of the right pulmonary artery. The thickness of the midthoracic descending aortic wall was measured using electronic calipers at 4 standard positions: 12, 3, 6, and 9 o'clock (QMASS 7.2). The average value of these 4 measurements was calculated.
Mean characteristics of the MESA5 participants
At MESA5 (2010-2011), mean±SD
Race (N of white/black)
Body mass index (kg/m2)
Systolic blood pressure (mmHg)
Diastolic blood pressure (mmHg)
Metabolic Syndrome, N (%)*
LV End diastolic volume (ml)
LV End systolic volume (ml)
LV End diastolic mass (g)
LV Stroke volume (ml)
LV Ejection Fraction (%)
Aortic wall thickness (mm)
Wall thickness difference in ten years (mm)
We report aortic wall thickness changes over mid to late adulthood in longitudinal comparisons. Further analyses will reveal the correlates of these alterations with clinical variables.
N01-HC-95168 from the National Heart, Lung, and Blood Institute
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.