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Quantification of aortic pulse wave velocity in preterm infants using 4D phase contrast MRI
© Broadhouse et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Preterm Infant
- Pulse Wave Velocity
- Aortic Pulse Wave Velocity
- Paediatric Subject
- Aortic Distance
4D phase contrast (PC) MRI sequences providing full coverage of the aortic arch were acquired in neonates. Aortic pulse wave velocity (PWV) was then calculated from flow measurements taken at 5 to 8 locations along the arch and the aortic length between each location. Neonatal PWV values were compared with previously published adult values.
Mechanical compliance within the healthy and diseased aorta has been well documented in adults and paediatrics [1, 2]. Metafratzi et al  reported a PWV range from 4 to 10 ms-1 in the healthy adult aorta, whilst Vulliemoz et al found a mean PWV of 4.4 ms-1 . PWV is an inverse measure of vessel compliance and marker for vessel stiffness. A significant increase in PWV has been found in paediatric subjects born prematurely at low birthweight when studied at ~8yrs and may explain the increase in cardiac disease in this population. However PWV models do not extend back to preterm infants. Recent studies in adults have used PC MRI flow data to determine PWV .
Assess feasibility of measuring aortic PWV in preterm and term infants using 4D PC MRI, in order to establish a normative range in this population and facilitate comparison with adult values.
9 infants median (range) corrected GA 32(30+4-36+5) weeks and weight at scan 1330(875-2070) grams were scanned. Mean (range) PWV was found to be 3.2(2.3-5.1)ms-1.
In this initial study PWV velocity in neonates was found to be at the lower end of reported adult ranges.
MRC studentship funding
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.