- Moderated poster presentation
- Open Access
4D flow MRI demonstrates altered aortic hemodynamics in patients with right-left and right-noncoronary bicuspid aortic valve fusion patterns
© Mahadevia et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Bicuspid Aortic Valve
- Peak Systolic Velocity
- Flow Angle
- Systolic Flow
- Valve Morphology
Altered aortic hemodynamics associated with bicuspid aortic valve (BAV) have been implicated in the development of aortopathy in patients with congenitally altered valves. Most studies have focused on the most common "right-left" bicuspid aortic valve (RL-BAV) fusion pattern . This study assessed the effects of valve morphology on aortic 3D blood flow in cohorts with the most common RL-BAV fusion, less common right-noncoronary (RNC-BAV), and normal trileaflet valves.
p-value (student's t-test)
(Control v. RL)
(Control v. RNC)
(RL v. RNC)
Aortic Insufficiency (moderate-severe)
Aortic Stenosis (moderate-severe)
Diameter (cm) Mid Ascending Aorta
Peak Velocity (m/s) Mid Ascending Aorta
Peak Velocity (m/s) Mid Aortic Arch
Peak Velocity (m/s) Mid Descending Aorta
The presence and type of BAV fusion was clearly associated with changes in systolic flow uniformity, peak systolic velocities, and flow angles. Flow jet patterns directed towards the aortic wall in BAV patients identify potential mechanisms for altered wall shear forces and aortopathy. Compared to RL-BAV, RNC-BAV showed more variable post-valve hemodynamics, indicating the potential for more complex and diverse outcomes in RNC-BAV subtypes. Future longitudinal studies are thus warranted to evaluate the impact of BAV valve morphology and altered hemodynamics on variability in aortopathy development.
NIH R01HL115828; NUCATS Dixon Award
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.