- Oral presentation
- Open Access
A multi-center trial of LGE-MRI of the left atrium
© Kholmovski et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Left Atrium
- Late Gadolinium Enhancement
- Atrial Fibrillation Patient
- Poor Quality Image
- Late Gadolinium Enhancement Image
Atrial fibrillation (AF) is the most common rhythm disturbance. Radio-frequency ablation (RFA) of the left atrium (LA) is effective for drug refractory AF patients. Outcome of RFA procedure depends on the degree of pre-ablation LA fibrosis and amount of post-ablation scar. Late gadolinium enhancement (LGE) imaging can detect fibrosis and visualize scar. However, only few centers with advanced expertise in cardiac MR (CMR) have demonstrated successful LGE of LA. Multi-center study was initiated to study reproducibility of LGE of LA.
Type of contrast agent and dosage in the participating sites
The number of centers
0.15, 0.15, 0.2
0.1, 0.2, 0.2, 0.2
370 AF patients underwent LGE-MRI within 30 days prior to RFA. LGE-MRI was repeated for 270 AF patients at least 3 months after RFA to quantify post-ablation scar. Quality of LGE images was scored by two experienced blinded readers: good - 2, fair - 1, poor - 0. In cases of score discrepancy, consensus was achieved by the readers. Poor quality images were not clinically useable. Good and fair quality images can be used for fibrosis and scar quantification. Poor quality images and supporting data (heart rhythm and rate, navigator signal, etc.) were analyzed to find the main reason for scan failure.
Image quality of pre- and post-ablation LGE-MRI of the left atrium
1.5 & 3T
1.5 & 3T
The multi-center trial demonstrates that it is possible to consistently acquire clinically useable LGE of LA using customized sequences and imaging protocols in centers without advanced CMR expertise utilizing typical MRI hardware and contrast agents. Better training in LA imaging for MRI technologists, may further improve image quality of LGE of LA.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.