- Oral presentation
- Open Access
Histological validation of dynamic-equilibrium cardiovascular magnetic resonance for the measurement of myocardial extracellular volume
© Miller et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Cardiovascular Magnetic Resonance
- Late Gadolinium Enhancement
- Collagen Volume Fraction
- Inversion Recovery Imaging
- Histological Validation
Extracellular matrix expansion is fundamental to left ventricular (LV) remodeling, and is a therapeutic target. CMR techniques are increasingly used to evaluate myocardial extracellular volume (ECV), however the most widely applied methods are without histological validation. The aim of this study was to provide whole-heart, histological validation of; 1. Dynamic-equilibrium CMR (DynEq-CMR), where ECV is quantified using hematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus; and 2. Isolated measurement of myocardial T1 at a fixed time-point following gadolinium bolus, used as an ECV surrogate.
DynEq-CMR-derived ECV shows a good correlation with histological CVF throughout the whole heart. Isolated post-contrast T1 measurement is insufficient for ECV assessment.
Christopher Miller is supported by a Doctoral Research Fellowship from the National Institute of Health Research (UK).
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.