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Myocardial tissue characterisation with late gadolinium enhancement in rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis
Journal of Cardiovascular Magnetic Resonance volume 15, Article number: O47 (2013)
Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) commonly involve the cardiovascular system, and are associated with high morbidity and mortality. Mechanisms of cardiovascular disease (CVD) involvement in these clinical entities are not fully understood. Furthermore, little is known about myocardial structure and function in these inflammatory arthropathies. Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging is a tool for noninvasive evaluation of myocardial fibrosis that has the advantage over other imaging techniques of being able to directly visualise both ischaemic and non-ischaemic patterns of injury, and has prognostic significance. The purpose of this study was to assess the frequency and pattern of LGE in RA, SLE and SSc patients without any known CVD using CMR and to determine its relation to disease duration, vascular function (aortic distensibility; pulse wave velocity) and left ventricular (LV) systolic function (LV ejection fraction; mid short axis circumferential systolic strain).
59 RA patients (42 female, mean age 53 ± 12), 29 SLE patients (28 female, mean age 42 ± 10), 18 SSc patients (17 female, mean age 55 ± 10), 45 normal controls (38 female, mean age 44 ± 12), and 14 controls with cardiovascular risk factors [CVRFs] (11 female, mean age 52 ± 8) underwent CMR at 1.5 Tesla. All patients with previously known CVD were excluded. Biventricular volumes and function, presence and pattern of LGE, myocardial strain and vascular function were assessed by CMR.
LGE was found to occur in 46% of RA, 31% of SLE and 50% of SSc patients compared to 9% of normal controls and 21% of controls with CVRFs (p<0.001). The patterns of LGE are presented in Table 1. Presence of LGE correlated with disease duration (Rs= 0.33; p<0.001), myocardial strain (Rs= 0.29; p<0.001), and total aortic pulse wave velocity (Rs= 0.72; p<0.001).
CMR demonstrates an increased burden of both ischaemic and non-ischaemic fibrosis in patients with inflammatory systemic diseases with no known CVD. Increased myocardial fibrosis may contribute to the poor cardiovascular outcomes in this group of patients. LGE in RA, SLE and SSc correlates with increasing disease duration, impaired myocardial strain, and increased pulse wave velocity.
NN is funded by the Discovery Foundation and Nuffield Trust. SN acknowledges support from the British Heart Foundation Centre of Research Excellence, Oxford. The research was funded through an investigator-led grant from GSK.
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Ntusi, N.A., Francis, J.M., Matthews, P.M. et al. Myocardial tissue characterisation with late gadolinium enhancement in rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis. J Cardiovasc Magn Reson 15 (Suppl 1), O47 (2013). https://doi.org/10.1186/1532-429X-15-S1-O47
- Rheumatoid Arthritis
- Systemic Lupus Erythematosus
- Cardiovascular Magnetic Resonance
- Systemic Lupus Erythematosus Patient
- Late Gadolinium Enhancement