MR-based calf muscle perfusion index correlates with treadmill exercise test parameters in patients with peripheral arterial disease
© Clement-Guinaudeau et al; licensee BioMed Central Ltd. 2013
Published: 30 January 2013
The functional impairment caused by peripheral arterial disease (PAD) is difficult to evaluate objectively and quantitatively. Current methods used to assess the efficacy of therapeutic interventions in patients with PAD are limited by variability and changes representing the placebo effect. Recently, Gadolinium-enhanced first-pass (FP) MRI has emerged as a new method to assess perfusion in peripheral muscles at peak exercise.
We seek to demonstrate that calf muscle perfusion index measured with FP MRI at peak exercise correlates with treadmill exercise measures of ischemia in patients with PAD.
62 patients were able to complete both the MRI and treadmill test. The PI measured by MRI correlated significantly with both times measured during the treadmill exercise test, the TWT and the COT (r =0.33 p<0.01, r=0.29 p=0.01, respectively). The PI was not correlated with resting ABI.
MR-based calf muscle PI correlates significantly with treadmill exercise parameters. MRI PI could be a valuable tool to objectively and quantitatively assess improvement in exercise perfusion in response to therapeutic intervention in patients with PAD.
Funding was provided by a grant from the National Institutes of Health (RC2HL101515 to Arshed Quyyumi, MD).
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.