- Oral presentation
- Open Access
Dual-IR late gadolinium enhancement achieves better blood suppression than traditional IR in a swine model of atrial radiofrequency ablation scar
© Peel et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Late Gadolinium Enhancement
- Swine Model
- Late Gadolinium Enhancement Image
- Blood Suppression
- Late Gadolinium Enhancement Area
A good correlation has been found between the extent of late gadolinium enhancement (LGE) and clinical outcome in patients who have undergone radiofrequency (RF) ablation for atrial fibrillation (AF). Residual blood signal with the traditional inversion-recovery (IR) sequence often hampers scar visualization in these patients and causes poor repeatability of scar size measurements. The dual-IR sequence has previously been shown to improve blood suppression in LGE images of myocardial infarction. We sought to assess whether the superior blood suppression with the dual-IR sequence would improve atrial scar definition in a swine model of chronic atrial radiofrequency ablation scar.
A 30 kg female Göttingen minipig pig underwent linear RF ablation from the SVC to the IVC under general anesthesia. MR imaging was performed two months later using a 1.5T MR scanner (Philips Healthcare, the Netherlands). After administering 0.2 ml/kg of Gadovist (Bayer Schering, Berlin), dual-IR imaging (imaging every heartbeat) was performed at 10 and 15 minutes and compared with standard IR imaging (imaging every 2 heartbeats) at 35 minutes.
The dual-IR pre-pulse consists of two non-selective inversion pre-pulses separated by two time delays (TI1 and TI2). The TI1 and TI2 delays were optimized to achieve signal suppression in the T1-range of 250-1400 ms. Whereas the IR sequence can only null one T1 species (e.g. normal myocardium), the dual-IR pre-pulse simultaneously suppresses both the blood and normal myocardium whilst maintaining high signal in the scar.
The dual-IR technique improves blood signal suppression and definition of the edges and boundaries of LGE areas. As dual-IR images were performed every heartbeat and taken earlier after contrast administration, it also has the potential to reduce the overall scan time.
This work was funded by the British Heart Foundation award RE/08/003 and EU COST Action: TD1007. The authors also acknowledge financial support from the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust and the Centre of Excellence in Medical Engineering funded by the Wellcome Trust and EPSRC under grant number WT 088641/Z/09/Z.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.