- Poster presentation
- Open Access
Marked variability in published CMR criteria for left ventricular basal slice selection - impact of methodological discrepancies on LV mass quantification
© Mullally et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Left Ventricular Mass
- Short Axis Slice
- Marked Variability
- Basal Slice
- Circumferential Extent
Left ventricular mass (LVM) quantification by cine-CMR is typically performed by planimetry of contiguous LV short axis images. This approach relies on use of anatomic landmarks or quantitative binary cutoffs to define the basal-most aspect of the LV. Methodological discordance concerning criteria for LV basal slice selection has the potential to alter cine-CMR quantified LVM. This study assessed frequency of methodological variability in published LV basal slice definitions, as well as its impact on cine-CMR quantification of LVM.
A Pubmed search was performed using the terms "left ventricular mass", "left ventricular hypertrophy", "myocardial mass", or "hypertrophy" AND "cardiac MRI", "CMR" or "magnetic resonance imaging" [species: human, language: English, publication date: after 1/1/00]. Manuscripts were reviewed by an AHA/ACC level III CMR trained physician for methodology concerning basal slice criteria; methods were categorized based on quantitative and anatomic criteria as defined in each manuscript. Published methods were then applied to an established registry of CAD patients: Cine-CMR images were planimetered for percent circumferential LV myocardium and basal-most LV short axis slices were assigned using the most common quantitative cutoffs determined by literature review.
Marked variability exists in published CMR literature regarding anatomic and quantitative criteria to define the basal-most LV on short axis cine-CMR. Application of established binary cutoffs frequently excludes LV myocardium from CMR measurements, resulting in 3-13% decrements in calculated LVM.
K23 HL 102249-01, Lantheus Medical Imaging (unrestricted research grant)