- Poster presentation
- Open Access
Established binary cutoffs for cine-CMR basal slice selection - an unrecognized source of CMR discordance with echocardiography and necropsy derived LV mass
© Simprini et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Short Axis
- Left Ventricular Mass
- Short Axis Slice
- Short Axis Image
- SSFP Image
Left ventricular mass (LVM) is widely used to guide clinical decision-making. CMR is well suited to measure LVM as it provides high-resolution delineation of myocardial contours. CMR quantification of LVM is typically performed via planimetry of contiguous short axis images, an approach fundamentally dependent on reader selection of short axis images to be contoured. Established methods have applied different binary cutoffs using circumferential extent of LV myocardium to define the basal LV, while omitting short axis images containing lesser fractions of LV myocardium. This study compared LVM, quantified using different established methods for basal slice selection, to independent references of LVM measured by echocardiography and necropsy.
Cine-CMR (1.5T) was performed in patients and laboratory animals. Contiguous short axis SSFP images were acquired throughout the LV; myocardial circumference was quantified in all short axis slices. LVM was quantified with inclusion of all LV myocardium (ALL), and by two previously established methods that use different binary cutoffs to define the LV basal-most short axis slice: (1) 50% circumferential myocardium at end-diastole alone (ED50), (2) 50% circumferential myocardium throughout both end-diastole and end-systole (EDS50). Patient results were compared to LVM quantified by echocardiography performed within 1 day of CMR. Lab animal results were compared to LV weight at necropsy.
Established CMR methods yield frequent discordance regarding assignment of the basal-most short axis LV slice, resulting in significant differences in calculated LVM. Inclusion of all myocardium, rather than use of binary cutoffs for basal slice selection, yields smallest CMR discrepancy with echocardiography measured LVM and non-significant differences with necropsy measured LV weight.
K23 HL102249-01, Lantheus Medical Imaging (unrestricted research grant)
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.