- Poster presentation
- Open Access
Extracellular volume imaging by T1 mapping cardiovascular magnetic resonance in patients with clinically suspected myocarditis
© Radunski et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Cardiovascular Magnetic Resonance
- Late Gadolinium Enhancement
- Final Study Population
- Extracellular Volume Fraction
Assessing the extracellular volume fraction (ECV) by T1 mapping is a promising cardiovascular magnetic resonance (CMR) approach to quantify myocardial injury. This study evaluated ECV imaging by T1 mapping CMR in patients with clinically suspected myocarditis.
The final study population consisted of 96 patients after exclusion of 17 patients with concomitant coronary artery disease or severe left ventricular hypertrophy. Current clinical and CMR criteria identified 64 (67 %) patients with myocarditis and 32 (33 %) patients without myocarditis in the final study population. Global ECV was significantly larger in patients with myocarditis compared to patients without myocarditis (35±6 vs. 30±5 %, p<0.0001). Furthermore, global ECV was significantly larger in patients with focal scar compared to patients without focal scar on LGE CMR (35±5 vs. 33±7 %, p<0.05). ROC analysis revealed a sensitivity of 73 % and a specificity 67 % to identify patients with myocarditis using a global ECV ≧ 32 % cut-off (AUC = 0.76, p<0.0001).
Patients with myocarditis are characterized by an increased global ECV. Assessing global ECV by T1 mapping has great potential to improve the diagnostic and prognostic impact of CMR in patients with clinically suspected myocarditis.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.