- Poster presentation
- Open Access
Reproducibility of quantitative analysis of aortic 4D flow data
© Dyverfeldt et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Wall Shear Stress
- Aortic Dilation
- Aortic Blood Flow
- Sinotubular Junction
- Blinded Reviewer
3D cine phase-contrast CMR ("4D Flow") permits quantitative assessment of anomalous alterations of aortic blood flow. Two hemodynamic parameters that have been used for this purpose is the wall shear stress (WSS), which is known to regulate endothelial cell function, and the normalized flow displacement from the vessel center, which was recently shown to correlate with increased growth rates of ascending aortic dilation [1, 2]. Analysis of these hemodynamic parameters requires that a user 1) positions a 2D plane of interest in the volumetric 4D Flow dataset and 2) delineates the contour of the vascular lumen in this 2D plane. We set out to assess the reproducibility of 4D Flow-based estimation of WSS and normalized flow displacement at these two critical levels of user-interaction. Furthermore, we assessed which of the parameters correlate best with aortic growth.
25 patients previously studied with 4D Flow imaging were included. Previously reported data on interval aortic growth was available for each subject .
Reproducibility analysis: inter-observer correlations
Mean peak-systolic WSS
Max peak-systolic WSS
Min peak-systolic WSS
Max systole-averaged WSS
Min systole-averaged WSS
Normalized Flow Displacement
Observerplanes#1 versus Observerplanes#2
Observercontours#1 versus Observercontours#2
Normalized flow displacement is a reproducible hemodynamic marker that shows good correlation with interval aortic growth. Reproducibility of contour delineation for WSS analysis was good and in line with previous reports . However, markedly lower reproducibility was found for the plane positioning step of the WSS analysis. Normalized flow displacement should be considered in future work aimed at identifying and risk-stratifying patients who are likely to develop clinically significant aortic dilation based on CMR-estimated hemodynamic parameters.
Covidien/Radiologic Society of North America Research Scholar Grant 2012-2014.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.