Figure 2

A) CMR measured circumferential strain (Ecc) rate is significantly reduced in diabetic mice (4.24 ± 0.28 1/s) compared with controls (5.94 ± 0.19 1/s). B) End-diastolic pressure volume relationship (EDPVR) measured by invasive pressure-volume loop analysis shows a significantly steeper EDPVR in diabetic mice (0.38 ± 0.04) compared with controls (0.21 ± 0.03). C) Relationship of invasive EDPVR to CMR measured Ecc rate.