Volume 15 Supplement 1
Transmural variations of vasodilator-induced changes of myocardial oxygenation vary with age and the presence of diabetes mellitus type II: a study using oxygen-sensitive cardiovascular MR
© Luu et al; licensee BioMed Central Ltd. 2013
Published: 30 January 2013
Diabetes is a chronic disease process, which precedes the development of microvascular dysfunction, detectable as circumferential, subendocardial perfusion deficits on imaging. The full effect of this chronic disease process on myocardial oxygenation is, however, unknown. Studies using oxygen-sensitive Cardiovascular Magnetic Resonance (OS-CMR) have shown that pharmacologically induced vasodilation leads to an increase of myocardial oxygenation. We hypothesized that in patients with type 2 diabetes, there is an impaired increase of myocardial oxygenation.
We measured the relative change of myocardial oxygenation during adenosine infusion in eight patients with type 2 diabetes (53±7 yrs, 6 male) and compared results to 11 healthy volunteers (29±4 yrs, 6 male), and 17 controls matched for age, gender and BMI (51±10 yrs, 13 male), all with no history of ischemic heart disease. Using a clinical 1.5T MRI system, OS-CMR was performed at baseline and during adenosine infusion (140 μg/kg/min) in three short axis slices in the study group and a single, mid-ventricular slice for the healthy volunteers. Myocardial signal intensity (SI) was measured in the whole myocardium, as well as separately in subepicardial and subendocardial layers.
Mean BOLD signal intensity percent changes for the whole myocardium, subendocardium, and subepicardium in study participants.
Whole myocardial SI Δ
Subendocardial SI Δ
Subepicardial SI Δ
Healthy volunteers (n=11 patients; 66 segments)
21.19% (95% CI 14.51 to 27.88)
21.34% (95% CI 14.15 to 28.53)
21.02% (95% CI 14.51 to 27.52)
Matched controls (age, gender, BMI) (n=17 patients; 211 segments)
7.42% (95% CI 6.12 to 8.71)
4.92% (95% CI 3.44 to 6.39)
10.17% (95% CI 8.82 to 11.51)
Diabetics (n=8; 100 segments)
6.21% (95% CI 4.01 to 8.40)
1.71% (95% CI -0.61 to 4.03)
10.85% (95% CI 8.46 to 13.22)
Compared with a healthy and young population, middle-aged subjects demonstrate a transmural gradient of vasodilator-induced changes of myocardial oxygenation. Compared with matched controls, however, patients with diabetes demonstrate a more severely impaired subendocardial response. Oxygen-sensitive CMR may serve as a valuable tool to non-invasively detect microvascular dysfunction in diabetes.
Canadian Diabetes Association; Alberta Innovates Health Solutions
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.