Figure 1
From: Transmyocardial therapeutic-delivery using real-time MRI guidance
(a) Needle catheter showing microcoils and extended nitinol injection needle. (b) Portions of the heart segmented on cine stack (TR/TE=3.4/1.54 ms, voxel=1.3x1.3x5 mm-cube, FA 43 degrees) are used to build 3d model of the left, right ventricle and infarcted region. (c) 3D model overlaid into real-time MR images is used to (d) navigate the catheter to pre-defined injection targets. Catheter model is built from MR images of active tracking coils. (e) Injection of iron-oxide laden therapeutic into myocardium (yellow arrow) monitored under real-time MRI. TR/TE=2.8/1.19 ms, voxel=1.9x1.9x5 mm3, FA/tracking FA =50/15 degrees, 1.5-4 frames/s. (f, g) Pre- and post-injection MRI confirms injection of microbeads. TR /TE = 6.8/3.25 ms, FA=30 degrees, voxel =1.0×1.0×5.0 mm-cube.