- Poster presentation
- Open Access
Transmyocardial therapeutic-delivery using real-time MRI guidance
© Hegde et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Intramyocardial Injection
- Stem Cell Product
- Single Stem Cell
- Injection Catheter
- Alginate Microbeads
Catheter-based transmyocardial injection offers a minimally invasive method to deliver therapeutics to the heart. It is typically performed under X-ray fluoroscopic guidance, which suffers from poor demarcation of myocardial boundaries and an inability to assess myocardial viability. MRI-guided intramyocardial delivery of therapeutics at 3T offers the potential for more precise targeting of these therapies with superior tissue contrast. Our group has been actively involved with microencapsulated stem cell therapy to improve cell retention and prevent stem cell rejection. However, conventional microencapsulated stem cell products are too large to be administered transmyocardially. We demonstrate here intramyocardial injection of a prototype single stem cell therapeutic into the myocardium of a normal swine using real-time MR guidance and a custom active injection catheter.
Left ventricular catheterization and guidance to four target sites in the myocardium was achieved. Confirmation of microbead delivery on FLASH images was possible but difficult due to the small volume and low iron concentration delivered. Follow-up imaging at one week post-delivery was unable to visualize the iron oxide-labeled therapeutic. No adverse events from transmyocardial delivery were observed.
A real-time interface with active catheter tip tracking enabled successful 3T MRI-guided transmyocardial delivery of a prototype therapeutic to the in vivo heart.
MD Stem Cell Research Foundation (2011-MSCRFII-0043) and Siemens Corporation
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.