- Poster presentation
- Open Access
Standardization of myocardial T1 time measurements in clinical setting using MOLLI, shMOLLI and LL at 1.5T and 3T - the CONSEPT study
© Rogers et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Late Gadolinium Enhancement
- Late Gadolinium Enhancement Image
- Gadolinium Enhancement Image
- Cardiac Magnetic Resonance Finding
- Septal Myocardium
MMeasurement of myocardial T1 mapping is possible with most of the clinically used magnets using sequences based on modification (MOLLI) or shortening (shMOLLI) of the Look-Locker (LL) sequence. However, the robustness of T1 post-processing approaches has not been systematically examined for these sequences, nor for different field strengths, in native and post-contrast T1 maps. Moreover, repeatability of measurements in conditions with altered geometric relations of cardiac chambers and wall thickness commonly observed in clinical settings remains unknown.
T1 times derived in septal myocardium showed excellent intra and inter-observer repeatability at both field strengths and in all diagnosis categories (CoV=1.5- 4.1). In contrast, lateral wall T1 time measurements showed considerably wider inter-observer variability (CoV=2.4-9). In addition, the CoVs were significantly higher in at 1.5T field strength, shMOLLI, and LL sequence (p<0.05). Regionally reduced signal-to noise ratio, sampling error from voxels straddling the myocardial-blood pool interface and measurement error in the lateral wall underlined the greater inter-observer variability in the lateral wall compared with the septum.
We demonstrate that measurement of T1 values using conservative septal technique (CONSEPT) is robust and repeatable in healthy subjects and also in patients with significantly altered chamber relations. We propose the CONSEPT approach as the standardized post-processing method for T1 value derivation in clinical setting.
National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.