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- Open Access
High-resolution quantitative 3D T2 mapping allows quantification of changes in edema after myocardial infarction
© Ding et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Late Gadolinium Enhancement
- Microvascular Obstruction
- Post Myocardial Infarction
- Left Ventricle Volume
- Phase Sensitive Inversion Recovery
T2 values are related to the tissue water content, providing useful diagnostic information in cardiac diseases, especially in acute states such as myocardial infarction (MI). Visualization of edema, its regional distribution, and extent in acute and chronic heart disease may be useful as a diagnostic tool and help in guiding treatment in the patients with heart disease. Recently, edema detection (T2 elevation) using quantitative T2 maps has been shown more robust than qualitative clinical T2W imaging.
Hypothesis: Whole heart coverage T2 mapping makes the global edema distribution available for quantitative myocardial edema assessment in the context of subacute MI.
Under IACUC-approved protocol, MI was induced in swine (N = 4) by 120 min occlusion of the mid LAD. Imaging was carried out 2 to 9 days post MI using an Achieva 3T TX system (Philips Healthcare, Best, Netherlands). Normal animals (N=4) were imaged for reference T2 values. T2-mapping of the ventricles was carried using previously presented free-breathing 3D sequence. Post-contrast 3D Late Gadolinium enhancement with phase sensitive inversion recovery (PSIR) images were acquired ~30min post infusion of 0.2 mmol/kg of Magnevist. Both sequences were acquired in high-resolution (~1.0x1.25x3 mm3 for PSIR, 1.25x1.25x5 mm3 for T2 Maps) during free-breathing using independent respiratory navigator gating.
3D T2 maps were calculated per voxel using linear regression of the log of the signal. Pixels with poor fits (corr. coeff. R2<0.9) were rejected. The left ventricle (LV) was manually segmented, excluding papillary muscle and epicardial/endocardial boundaries.
The high resolution quantitative T2 maps enables monitoring of physiological changes over time, providing an objective assessment on the evolution of edema post MI.
This work was funded in part by AHA-11SDG5280025.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.