- Poster presentation
- Open Access
Virtual chemical inversion - a novel fat suppression technique for T1-weighted cardiac imaging with improved delineation of the fat-myocardium interface
© Jenista et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Enhancement Imaging
- Signal Ratio
- Experienced Reader
- Suppression Technique
- Water Tube
Fat-saturation and T1-weighting are fundamental for tissue differentiation, but combining these techniques is challenging. For instance, standard chemically selective saturation (CHESS) pulses provide insufficient fat-suppression with routine delayed enhancement imaging . Fat-water separation using multi-echo Dixon techniques can robustly separate fat and water into individual images, but in the fat-suppressed (water only) image, fat may retain a significant amount of signal making identification of the fat-water border difficult.
We previously described a new technique (Virtual Chemical Inversion, VCI, ) which has the advantage of providing T1-weighted images with and without fat suppression in a single acquisition without the need for additional data acquisition, RF pulses, or increased scan time. In this study, we compare the ability of the CHESS, a multi-echo Dixon technique (VARPRO, ), and our new method (VCI) to completely delineate the myocardium-fat interface in patients, and the level of fat suppression in phantoms.
Phantoms - A phantom with tubes of oil and water was imaged at 1.5T (MAGNETOM Avanto) using CHESS, VARPRO and VCI. B0 offsets ranging from 0 Hz to 100 Hz were tested. Regions of interest (ROIs) were drawn in the fat and water tubes and fat suppression was evaluated by calculating the fat-water signal ratio.
Patients - Patient images were acquired in 10 consecutive patients at 1.5T with VARPRO, VCI, and DIR-TSE with SPAIR, a commonly used method for pre-contrast fat suppression . Two experienced readers estimated the percentage of the visible RV myocardium - fat interface. ROIs were drawn in the myocardium and pericardial fat. The ratio of fat to myocardium signal was calculated. Analyses were performed using ANOVA with Bonferroni correction.
VCI exhibited excellent fat-water separation in both phantoms and patients, consistently providing fat suppression to a higher degree than both DIR-TSE and VARPRO, allowing for nearly complete delineation of the RV myocardium- fat interface.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.