- Poster presentation
- Open Access
First-pass myocardial perfusion imaging with whole ventricular coverage using L1-SPIRIT accelerated spiral trajectories
© Yang et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Cardiac Magnetic Resonance
- Compress Sensing
- Short Axis Slice
- Stress Cardiac Magnetic Resonance
- Data Fidelity Term
First-pass perfusion imaging using cardiac magnetic resonance (CMR) has become clinically applicable as an important tool for diagnosing coronary artery disease. We have recently demonstrated that high quality first-pass images can be acquired with an optimized spiral pulse sequence, but this sequence is only capable of imaging 3 short axis slices of the heart for a maximum heart rate of 110 bpm. In order to achieve whole ventricular coverage, we have developed an accelerated spiral sequence using the Parallel Imaging and Compressed Sensing technique L1-SPIRIT.
To evaluate and develop the accelerated reconstruction we retrospectively down-sampled data acquired from a fully-sampled variable density (VD) spiral perfusion data set acquired on a 1.5T scanner. Pulse sequence parameters included: TE 1.0 ms, TR 11 ms, FOV 320 mm2, in-plane resolution 1.75 mm, 8 interleaves, readout duration 8.1ms per interleave, saturation time 8 ms. We then designed a 4x accelerated pulse sequence which prospectively collected only 2 of 8 interleaves, and collects two perfusion images after each saturation pulse. Resting perfusion imaging was performed after injection of 0.1 mmol/kg of Gd-DTPA. Proton-density images acquired at the beginning of the acquisition were used to train the SPIRIT calibration kernel. Data reconstruction was performed using an iterative conjugate gradient reconstruction including a data fidelity term, SPIRIT calibration consistency term and an L1-finite difference in time as the sparsifying transform. Reconstruction was implemented in Matlab.
We demonstrated the successful application of whole ventricular coverage first-pass myocardial perfusion imaging using accelerated spirals. This sequence can acquire 8 short axis slices in 480ms enabling full ventricular coverage at heart rates up to 125 BPM. Further validation will be required in patients undergoing adenosine stress CMR.
This work was supported by grants from AHA 10SDG2650038 and NIH K23 HL112910-01.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.