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Regional variation in myocardial blood flow in patients with left bundle branch block evaluated with quantitative perfusion CMR
© Motwani et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Myocardial Perfusion Imaging
- Myocardial Blood Flow
- Perfusion Defect
- Left Bundle Branch Block
- Lateral Region
This study is the first to use quantitative perfusion CMR to evaluate regional differences in myocardial blood flow (MBF) in patients with left bundle branch block (LBBB).LBBB is often associated with underlying CAD but its presence can limit the diagnostic accuracy of non-invasive imaging tests. In particular, there is a high incidence of false-positive results with exercise SPECT due to apparent septal perfusion defects. The use of vasodilator stress has reduced but not eliminated this problem. Several hypotheses have been postulated to explain the cause of such perfusion defects, and these include early activation of the septum, leading to shortened diastole and reduced blood flow; partial volume effects caused by impaired septal thickening; and increased septal intra-myocardial pressure during diastole, resulting in reduced flow reserve. A number of small studies using PET or early quantitative SPECT techniques have evaluated regional differences in MBF in patients with LBBB, but the results have been conflicting and have shown either no regional differences or a relative but not absolute reduction in septal perfusion. This study re-evaluates the unresolved question of septal perfusion in LBBB using quantitative perfusion CMR.
9 patients with LBBB and no significant CAD underwent adenosine stress/rest perfusion CMR at 1.5T and X-ray coronary angiography. Absence of CAD was defined as luminal stenosis <40% on quantitative coronary angiography in all major vessels. Mid-ventricular perfusion data were segmented into 3 regions for each patient: septal, adjacent (anterior-inferior) and lateral. MBF and myocardial perfusion reserve (MPR) were then determined for the septal and lateral regions by Fermi function deconvolution.
Regional Myocardial Blood Flow Estimates in Patients with LBBB
Stress MBF (ml/g/min)
Rest MBF (ml/g/min)
3.99 ± 1.03
4.62 ± 0.96
1.27 ± 0.26
1.27 ± 0.23
3.19 ± 0.78
3.71 ± 0.88
This study suggests that although septal perfusion remains normal in LBBB, there is a genuine relative reduction in MBF compared to the lateral wall. This phenomenon may account for the false positive results seen with myocardial perfusion imaging techniques and highlights a potential clinical utility of quantitative perfusion CMR.
JPG and SP receive an educational research grant from Philips Healthcare. SP is funded by a BHF fellowship (FS/1062/28409).
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.