- Poster presentation
- Open Access
Obesity has divergent effects on aortic stiffness in young and old adults
© Corden et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Arterial Stiffness
- Pulse Wave Velocity
- Adult Obesity
- Aortic Stiffness
- Bioelectrical Impedance Analysis
Aortic pulse wave velocity (PWV), a measure of central arterial stiffness, is an independent predictor of cardiovascular and all-cause mortality and has been associated with numerous cardiovascular risk factors. However, data on the association between obesity and aortic stiffness have been mixed, with some studies showing a positive association, others a negative association and others apposing effects between the sexes.
221 adult volunteers (127 female, age range 18-72 years, mean 40.3 years) were recruited via advertisement. Exclusion criteria included a history of cardiovascular-related disease, including hypertension, hypercholesterolemia and diabetes. Aortic arch PWV was calculated from the three dimensional vessel length and the transit time between the flow waveforms in the ascending and descending aorta, assessed using Magnetic Resonance Imaging (MRI). Total body fat mass was measured with multi-frequency bioelectrical impedance analysis.
The effect of obesity on aortic stiffness is age-dependant: in older adults being overweight predicts stiffer central arteries but it younger adults it predicts less stiff arteries. This finding helps explain the previously inconsistent findings within the literature and may relate to morphological and physiological differences between similar levels of obesity at different ages.
Medical Research Council
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.