- Poster presentation
- Open Access
4D flow jet shear layer detection method for the measurement of effective orifice area and assessment of aortic stenosis severity
© Garcia et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Aortic Stenosis
- Effective Orifice Area
- Transthoracic Doppler Echocardiography
- Valve Effective Orifice Area
- Acoustical Source Term
Aortic stenosis (AS) is the most common cause of valve replacement and its severity is mainly assessed by transthoracic Doppler echocardiography (TTE) to quantify valve effective orifice area (EOA) as determined by the continuity equation. In a previous study we demonstrated that EOA can be directly determined with 2D flow MRI downstream of the AS using the jet shear layer detection (JSLD) method and the acoustical source term (AST) concept. However, both TTE and 2D flow MRI rely on the measurement of local and single-directional velocities and thus incomplete assessment of the complex post-valve flow dynamics in a significant proportion of patients. 3D CINE phase contrast MRI with 3-directional velocity encoding (4D flow MRI) may improve EOA estimation by the JSLD method coupled with full volumetric coverage of ascending aortic 3D blood flow. The objective of this study was to validate 4D flow MRI based EOA estimation using an in-vitro stenosis phantom and to apply the technique for the in-vivo measurement of the valve EOA compared to the reference standard 2D flow MRI.
In-vitro test consisted of a glass stenosis model (pipe Ø 33.5±2.0mm, stenosis Ø 10±1.0mm, EOA= 0.78cm2) filled with a blood-mimicking fluid and measured at steady flow (5.7±0.5L/min). In-vivo study included 35 subjects: 10 healthy control subjects (60% men, age 39±11 years) and 25 patients (76% men, age 44±11 years) with mild to severe bicuspid AS (0.95cm2≤EOA≤4.56cm2). 4D flow MRI was performed at 1.5T and 3T system (Avanto, Skyra, Siemens, Germany). Data was acquired in a sagittal oblique slab covering the entire aorta (spatial resolution/temporal resolution=2.5×2.1×3.2mm3/40-50ms). As reference standard, EOA was calculated using continuity equation (EOA-CE=SV/VTIAo, where SV is the LV stroke volume and VTIAo is the aortic velocity-time integral using 2D flow MRI). The JSLD method (EOA-JSLD) was employed to calculate EOA from 4D flow data by using AST([▽(ωΛV)], where ω is vorticity and V is velocity field) to detect the post-valve jet-flow zone, i.e. EOA.
This study showed that valve EOA calculated using JSLD method can be easily obtained from 4D flow MRI measurements in AS patients and is in excellent agreement with standard techniques. This method may be useful for accurately grading the AS severity non-invasively without the use of SV or VTIs and thus minimizing measurement variability.
Grant support by NIH R01HL115828, NUCATS Dixon Award.