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- Open Access
Quantitative investigation of cardiac motion effects on in vivo diffusion tensor parameters: a simulation study
© Wei et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Fractional Anisotropy
- Diffusion Tensor Imaging
- Diffusion Weighted Image
- Human Heart
- Mean Diffusivity
Cardiac motion is a crucial problem in in vivo diffusion tensor imaging (DTI) of the human heart. Despite its importance, the effects of cardiac motion on diffusion tensor parameters of the human heart in vivo have not been well established, mainly because of large signal loss. Recently, an efficient method was proposed that acquires cardiac diffusion weighted (DW) images at different time points of the cardiac cycle and reduces motion-induced signal loss using PCA filtering and temporal MIP techniques (PCATMIP) (Rapacchi, Invest Radiol 2011). Meanwhile, polarized light imaging (PLI) provides us the ground-truth of the heart fiber architecture, and DENSE sequence offers us higher spatial resolution displacement fields of the human heart in vivo. These different imaging possibilities have led us to investigate a multimodal approach to quantitatively investigate the effects of cardiac motion on diffusion tensor parameters such as fractional anisotropy (FA), mean diffusivity (MD) and fiber angles.
This study demonstrates that cardiac motion introduces an overestimation for FA and MD. Using the proposed motion model and the PCATMIP method, measurement accuracy on diffusion tensor parameters was significantly improved, which suggests new solutions to the problem of getting insights into in vivo fiber architecture of the human heart.
This work was supported by the French ANR 2009 (under ANR-09-BLAN-0372-01).
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.