- Poster presentation
- Open Access
Black-blood dynamic contrast-enhanced carotid artery wall MRI with SRDIR preparation
© Fan et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Carotid Plaque
- Gadopentetate Dimeglumine
- Saturation Recovery
- Double Inversion Recovery
- Carotid Artery Wall
Inflammation plays a major role in atherosclerotic plaque progression and disruption . Dynamic gadolinium contrast-enhanced (DCE) vessel wall imaging has been used to compute a set of contrast kinetic parameters that may characterize the extent of inflammation of carotid plaques [2-4]. However, previous DCE techniques are limited to a 2D bright-blood acquisition and thus the accuracy of wall signal assessment could be compromised. This work aimed to develop a 3D black-blood DCE technique.
Nine healthy volunteers (7 F, 2 M; age 31-49 years) were scanned at 3T (Siemens Magnetom Verio) using a 4-channel bilateral carotid coil. The 3D DCE imaging using the SRDIR technique was conducted axially at the carotid bifurcations. Imaging parameters included: resolution = 0.6 × 0.6 × 2.0 mm3, 4 partitions, ECG triggering to minimize pulsation motion, 30 lines/RR, TI1/TI2 = 200/40 ms based on computer simulations. One-frame pre-contrast scan was followed by repetitive contrast-enhanced scans (40 s/frame, > 15 min), along with intravenous contrast (0.2 mmol/kg gadopentetate dimeglumine) injection and saline flush (30 ml) both at 0.2 ml/s. Through ROI analysis on the black-blood and bright-blood image series, respectively, the changes in signal intensity of carotid artery wall and lumen were obtained and used to compute the kinetic parameters (Ktrans, Kep, and Vp) based on Toft's two compartmental model.
Ktrans and Vp values obtained in this work were in accordance with previous studies. To our knowledge, this is the first work in which Kep is investigated for carotid vessel wall. The healthy volunteer data indicates that SRDIR is a promising dynamic carotid vessel wall imaging technique. Clinical validations are currently underway.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.